Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunity. 2009 Aug 21;31(2):259-69. doi: 10.1016/j.immuni.2009.06.016. Epub 2009 Jul 16.

Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.

Author information

  • 1Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia. d.gatto@garvan.org.au

Abstract

Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, but the signals that guide responding B cells to these alternative compartments have not been fully elucidated. Here, we show that expression of the orphan G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) by activated B cells was essential for their movement to extrafollicular sites and induction of early plasmablast responses. Conversely, downregulation of EBI2 enabled B cells to access the center of follicles and promoted efficient GC formation. EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.

PMID:
19615922
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk