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J Neurosurg. 2010 May;112(5):983-9. doi: 10.3171/2009.6.JNS0935.

Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome.

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  • 1Department of Neurosurgery, LSU Health Science Center-Shreveport, Louisiana 71130-3932, USA.


Whipple disease is a multisystem infectious disease caused by Tropheryma whippleii. It commonly affects the CNS and produces neurological symptoms in 10-20% of cases. Central nervous system Whipple disease occurring in patients with AIDS is extremely rare. The authors present a case of a newly diagnosed AIDS patient in whom intracranial Whipple disease was diagnosed by stereotactic brain biopsy.

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