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AIDS. 2009 Sep 24;23(15):2047-50. doi: 10.1097/QAD.0b013e328330342c.

The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.

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  • 1Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia.

Abstract

We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.

PMID:
19609198
[PubMed - indexed for MEDLINE]
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