Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia.
We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on