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Haematologica. 2009 Aug;94(8):1109-23. Epub 2009 Jul 16.

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas.

Bende RJ, van Maldegem F, van Noesel CJ.

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Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Abstract

Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.

PMID:: 19608670; [PubMed - indexed for MEDLINE]
PMCID:: PMC2719034

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