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Genes Dev. 2009 Jul 15;23(14):1625-30. doi: 10.1101/gad.1809209.

Epigenetic control of skull morphogenesis by histone deacetylase 8.

Author information

  • 1Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

Abstract

Histone deacetylases (Hdacs) are transcriptional repressors with crucial roles in mammalian development. Here we provide evidence that Hdac8 specifically controls patterning of the skull by repressing a subset of transcription factors in cranial neural crest cells. Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and this is phenocopied by conditional deletion of Hdac8 in cranial neural crest cells. Hdac8 specifically represses the aberrant expression of homeobox transcription factors such as Otx2 and Lhx1. These findings reveal how the identity and patterning of vertebrate-specific portions of the skull are epigenetically controlled by a histone deacetylase.

PMID:
19605684
[PubMed - indexed for MEDLINE]
PMCID:
PMC2714711
Free PMC Article

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