Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Genes Dev. 2009 Jul 15;23(14):1606-12. doi: 10.1101/gad.1827709.

Paused Pol II captures enhancer activity and acts as a potent insulator.

Author information

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.


Enhancers act over many kilobase pairs to activate target promoters, but their activity is constrained by insulator elements that prevent indiscriminate activation of nearby genes. In the July 1, 2009, issue of Genes & Development, Chopra and colleagues (pp. 1505-1509) report that promoters containing a stalled Pol II are activated by enhancers, but these promoters also serve as insulators that block enhancers from reaching more distal genes. This new class of insulators provide critical clues to regulatory mechanisms.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1.
Figure 2.
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk