Immunity. 2009 Jul 17;31(1):7-9.

Integr-ating IL-1 alpha in antiviral host defenses.

Source

Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu

Abstract

Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.

Comment on

Immunity. 2009 Jul 17;31(1):110-21.

PMID:: 19604487; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Comment

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. [Immunity. 2009]
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM. Immunity. 2009 Jul 17; 31(1):110-21. Epub 2009 Jul 2.
Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells. [J Immunol. 2009]
Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.
Elkabets M, Krelin Y, Dotan S, Cerwenka A, Porgador A, Lichtenstein RG, White MR, Zoller M, Iwakura Y, Dinarello CA, et al. J Immunol. 2009 Apr 15; 182(8):4874-81.
Pulmonary inflammation induced by incomplete or inactivated adenoviral particles. [Hum Gene Ther. 1995]
Pulmonary inflammation induced by incomplete or inactivated adenoviral particles.
McCoy RD, Davidson BL, Roessler BJ, Huffnagle GB, Janich SL, Laing TJ, Simon RH. Hum Gene Ther. 1995 Dec; 6(12):1553-60.
Review Strategies to overcome host immunity to adenovirus vectors in vaccine development. [Expert Rev Vaccines. 2009]
Review Strategies to overcome host immunity to adenovirus vectors in vaccine development.
Thacker EE, Timares L, Matthews QL. Expert Rev Vaccines. 2009 Jun; 8(6):761-77.
Review Engineered adenovirus serotypes for overcoming anti-vector immunity. [Expert Opin Biol Ther. 2009]
Review Engineered adenovirus serotypes for overcoming anti-vector immunity.
Dharmapuri S, Peruzzi D, Aurisicchio L. Expert Opin Biol Ther. 2009 Oct; 9(10):1279-87.

See reviews... See all...

Cited by 1 PubMed Central article

Review Innate immune sensing of DNA viruses. [Virology. 2011]
Review Innate immune sensing of DNA viruses.
Rathinam VA, Fitzgerald KA. Virology. 2011 Mar 15; 411(2):153-62. Epub 2011 Feb 18.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Integr-ating IL-1 alpha in antiviral host defenses.
Integr-ating IL-1 alpha in antiviral host defenses.
Immunity. 2009 Jul 17 ;31(1):7-9.

PubMed
The effect of caffeic acid phenethyl ester on the functions of human monocyte-de...
The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells.
BMC Immunol. 2009 Jul 16 ;10:39.

PubMed
Ethnic differences in the adaptation rate of HIV gp120 from a vaccine trial.
Ethnic differences in the adaptation rate of HIV gp120 from a vaccine trial.
Retrovirology. 2009 Jul 15 ;6:67.

PubMed
Effect of hypnosis on oral function and psychological factors in temporomandibul...
Effect of hypnosis on oral function and psychological factors in temporomandibular disorders patients.
J Oral Rehabil. 2009 Aug ;36(8):556-70.

PubMed
Identifying anomalous reports of putatively extinct species and why it matters.
Identifying anomalous reports of putatively extinct species and why it matters.
Conserv Biol. 2010 Feb ;24(1):189-96. Epub 2009 Jul 13 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: