Mol Nutr Food Res. 2009 Aug;53(8):1063-70.

Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials.

Source

Ecole Nationale de Biologie Appliquée á la Nutrition et á l'Alimentation (ENSBANA), Université de Bourgogne, 21000-Dijon, France. jc.lhuguenot@wanadoo.fr

Abstract

During the 1980s and 1990s, and at the EU level, the Scientific Committee for Food evaluated a number of phthalates that were being used, or were requested for use, as additives in plastics. At this time, peroxisome proliferation was considered as the pivotal effect on which toxicological evaluation of these chemicals was based. At the end of 1990s, a general consensus has been agreed that rodents are highly sensitive to the phenomenon of peroxisome proliferation and that this particular effect should not be used for human risk assessment. Consequently in 2004, it was requested from the newly created European Food Safety Authority to perform a new evaluation of the mainly used phthalates on the basis of existing data. This paper summarizes evaluations of butylbenzylphthalate, dibutylphthalate, diethylhexylphthalate.

PMID:: 19603396; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Teratogen Effect - Genetic Alliance

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation. [Food Addit Contam Part A Chem ...]
Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation.
Petersen JH, Jensen LK. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Nov; 27(11):1608-16.
Phthalate exposure through food and consumers' risk perception of chemicals in food. [Risk Anal. 2009]
Phthalate exposure through food and consumers' risk perception of chemicals in food.
Dickson-Spillmann M, Siegrist M, Keller C, Wormuth M. Risk Anal. 2009 Aug; 29(8):1170-81. Epub 2009 Apr 23.
Review Assessing exposure to phthalates - the human biomonitoring approach. [Mol Nutr Food Res. 2011]
Review Assessing exposure to phthalates - the human biomonitoring approach.
Wittassek M, Koch HM, Angerer J, Brüning T. Mol Nutr Food Res. 2011 Jan; 55(1):7-31.
Derivation of Biomonitoring Equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP). [Regul Toxicol Pharmacol. 2009]
Derivation of Biomonitoring Equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP).
Aylward LL, Hays SM, Gagné M, Krishnan K. Regul Toxicol Pharmacol. 2009 Dec; 55(3):259-67. Epub 2009 Sep 12.
Review Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study. [Environ Health Perspect. 2006]
Review Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study.
Calafat AM, McKee RH. Environ Health Perspect. 2006 Nov; 114(11):1783-9.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Recent European Food Safety Authority toxicological evaluations of major phthala...
Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials.
Mol Nutr Food Res. 2009 Aug ;53(8):1063-70.

PubMed
Clinical and metabolic features of urolithiasis and microlithiasis in children.
Clinical and metabolic features of urolithiasis and microlithiasis in children.
Pediatr Nephrol. 2009 Nov ;24(11):2203-9. Epub 2009 Jul 15 .

PubMed
The hepatic response to thermal injury: is the liver important for postburn outc...
The hepatic response to thermal injury: is the liver important for postburn outcomes?
Mol Med. 2009 Sep-Oct ;15(9-10):337-51. Epub 2009 Apr 10 .

PubMed
Intratracheal delivery of CX3CL1-expressing mesenchymal stem cells to multiple l...
Intratracheal delivery of CX3CL1-expressing mesenchymal stem cells to multiple lung tumors.
Mol Med. 2009 Sep-Oct ;15(9-10):321-7. Epub 2009 Jun 18 .

PubMed
The inverse association between cardiorespiratory fitness and C-reactive protein...
The inverse association between cardiorespiratory fitness and C-reactive protein is mediated by autonomic function: a possible role of the cholinergic antiinflammatory pathway.
Mol Med. 2009 Sep-Oct ;15(9-10):291-6. Epub 2009 Jun 6 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: