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Curr Med Chem. 2009;16(21):2641-52.

Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in atherogenesis: a brief review.

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  • 1Vascular Biology Institute, Department of Medicine, Winthrop-University Hospital, Suite 502, Mineola, NY 11501, USA. AReiss@winthrop.org

Abstract

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is regulated by a feed-forward system stimulated by oxidized LDL (oxLDL), a major component of atherosclerosis. LOX-1 is a homodimer with a reactive backbone that can bind to a host of different ligands, including small molecules, and whole cells. LOX-1 is involved in many intercellular, intracellular, and molecular processes that are atherogenic. LOX-1 levels are elevated within atherosclerotic plaques and its expression is induced by proinflammatory cytokines. The ability of LOX-1 to bind many different ligands and control several atherogenic processes makes this receptor a likely vascular disease biomarker as well as an ideal choice for drug therapy aimed at preventing cardiovascular disease.

PMID:
19601801
[PubMed - indexed for MEDLINE]
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