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Int J Obes. 1991 Sep;15(9):561-5.

Yohimbine does not affect fat distribution in men.

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  • 1Department of Family and Community Medicine, Lancaster General Hospital, PA 17603.


Forty-seven men with a mean age of 42 years were assigned in random, double-blind fashion to treatment with either placebo or high-dose yohimbine (peak dose, 43 mg/day). Thirty-three subjects completed the six-month program. Variables assessed throughout the study included: body weight and body mass index; total cholesterol and HDL; body fat; and fat distribution as measured both by waist-to-hip ratio and by CT scan. Treatment with yohimbine had no effect on any variable in comparison with the control group.

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