Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Front Neural Circuits. 2009 Jul 1;3:5. doi: 10.3389/neuro.04.005.2009. eCollection 2009.

Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity.

Author information

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA.

Abstract

We examined tyrosine hydroxylase (TH-GAL4) expression and anti-TH immunoreactivity in the Drosophila protocerebrum and characterized single cell clones of the TH-GAL4 neurons. Eight clusters of putative dopaminergic neurons were characterized. Neurons in three of the clusters project to the mushroom body neuropil: PAM neurons project to the medial portion of the horizontal lobes; PPL1 neurons project to the vertical lobes, the junction area, the heel and distal peduncle; and PPL2ab neurons project to the calyx. Five types of PPL1 neurons were discovered that innervate different zones of the mushroom body lobes. Functional imaging experiments showed that the dopaminergic processes in four of the zones differ in response properties to odor, electric shock, or following the pairing of odor and electric shock. These results indicate that distinct dopaminergic neurons define separate zones of the mushroom body lobes and are probably involved in different functions. Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes.

KEYWORDS:

Drosophila; dopamine; functional optical imaging; olfactory learning; single cell clones; tyrosine hydroxylase

PMID:
19597562
[PubMed]
PMCID:
PMC2708966
Free PMC Article

Images from this publication.See all images (8)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Write to the Help Desk