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    Nat Genet. 2009 Aug;41(8):879-81. doi: 10.1038/ng.416. Epub 2009 Jul 13.

    Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.

    Source

    National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. emelia@bu.edu

    Abstract

    We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

    PMID:
    19597492
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2761746
    Free PMC Article

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