Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Microbiol Rev. 2009 Jul;22(3):447-65. doi: 10.1128/CMR.00055-08.

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis.

Author information

  • 1Medical Microbiology and Immunology, University of Wisconsin-Madison, 3467 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USA.

Abstract

Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological niches. Almost 200 species of aspergilli have been identified, less than 20 of which are known to cause human disease. Among them, Aspergillus fumigatus is the most prevalent and is largely responsible for the increased incidence of invasive aspergillosis (IA) in the immunocompromised patient population. IA is a devastating illness, with mortality rates in some patient groups reaching as high as 90%. Studies identifying and assessing the roles of specific factors of A. fumigatus that contribute to the pathogenesis of IA have traditionally focused on single-gene deletion and mutant characterization. In combination with recent large-scale approaches analyzing global fungal responses to distinct environmental or host conditions, these studies have identified many factors that contribute to the overall pathogenic potential of A. fumigatus. Here, we provide an overview of the significant findings regarding A. fumigatus pathogenesis as it pertains to invasive disease.

PMID:
19597008
[PubMed - indexed for MEDLINE]
PMCID:
PMC2708386
Free PMC Article

Images from this publication.See all images (3)Free text

FIG. 1.
FIG. 2.
FIG. 3.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk