Semin Immunol. 2009 Oct;21(5):293-300.

CD40 and autoimmunity: the dark side of a great activator.

Source

Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA.

Abstract

CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and non-immune cells. CD40:CD154 interactions mediate T-dependent B cell responses and efficient T cell priming. Thus, CD40 is a likely candidate to play roles in autoimmune diseases in which activated T and B cells cause pathology. Diseases in which CD40 plays a pathogenic role include autoimmune thyroiditis, type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy.

PMID:: 19595612; [PubMed - indexed for MEDLINE]
PMCID:: PMC2753170

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Review

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Review The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway. [Autoimmunity. 2004]
Review The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway.
Toubi E, Shoenfeld Y. Autoimmunity. 2004 Sep-Nov; 37(6-7):457-64.
Review The role of CD40-CD154 interaction in cell immunoregulation. [J Biomed Sci. 2004]
Review The role of CD40-CD154 interaction in cell immunoregulation.
Xu Y, Song G. J Biomed Sci. 2004 Jul-Aug; 11(4):426-38.
Review Costimulatory molecule CD154 in systemic lupus erythematosus and rheumatoid arthritis. Therapeutic perspectives. [Roum Arch Microbiol Immunol. 2...]
Review Costimulatory molecule CD154 in systemic lupus erythematosus and rheumatoid arthritis. Therapeutic perspectives.
Dejica DI, Manea EM. Roum Arch Microbiol Immunol. 2006 Jan-Jun; 65(1-2):66-74.
Review [Involvement of CD40-CD154 interaction in immunopathogenesis of collagen diseases and its application to a novel therapeutic strategy]. [Nihon Rinsho Meneki Gakkai Kai...]
Review [Involvement of CD40-CD154 interaction in immunopathogenesis of collagen diseases and its application to a novel therapeutic strategy].
Harigai M. Nihon Rinsho Meneki Gakkai Kaishi. 2004 Dec; 27(6):379-88.
Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes. [Hematology. 2007]
Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes.
Meabed MH, Taha GM, Mohamed SO, El-Hadidy KS. Hematology. 2007 Aug; 12(4):301-7.

See reviews... See all...

Cited by 9 PubMed Central articles

CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies. [PLoS One. 2012]
CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies.
Wolf D, Jehle F, Ortiz Rodriguez A, Dufner B, Hoppe N, Colberg C, Lozhkin A, Bassler N, Rupprecht B, Wiedemann A, et al. PLoS One. 2012; 7(3):e33026. Epub 2012 Mar 8.
Review The role of CD40/CD40 ligand interactions in bone marrow granulopoiesis. [ScientificWorldJournal. 2011]
Review The role of CD40/CD40 ligand interactions in bone marrow granulopoiesis.
Mavroudi I, Papadaki HA. ScientificWorldJournal. 2011; 11:2011-9. Epub 2011 Oct 26.
Review CD154: an immunoinflammatory mediator in systemic lupus erythematosus and rheumatoid arthritis. [Clin Dev Immunol. 2012]
Review CD154: an immunoinflammatory mediator in systemic lupus erythematosus and rheumatoid arthritis.
Alaaeddine N, Hassan GS, Yacoub D, Mourad W. Clin Dev Immunol. 2012; 2012:490148. Epub 2011 Oct 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

CD40 and autoimmunity: the dark side of a great activator.
CD40 and autoimmunity: the dark side of a great activator.
Semin Immunol. 2009 Oct ;21(5):293-300.

PubMed
Cell growth stimulation by EGF: inhibition through antisense-oligodeoxynucleotid...
Cell growth stimulation by EGF: inhibition through antisense-oligodeoxynucleotides demonstrates important role of casein kinase II.
Exp Cell Res. 1991 Dec ;197(2):245-53.

PubMed
AHRQ series paper 5: grading the strength of a body of evidence when comparing m...
AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions--agency for healthcare research and quality and the effective health-care program.
J Clin Epidemiol. 2010 May ;63(5):513-23.

PubMed
Prevalence of adult atopic dermatitis among nursing staff in a Taiwanese medical...
Prevalence of adult atopic dermatitis among nursing staff in a Taiwanese medical center: a pilot study on validation of diagnostic questionnaires.
J Am Acad Dermatol. 2009 Nov ;61(5):806-12.

PubMed
11-year follow-up of mortality in patients with schizophrenia: a population-base...
11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study).
Lancet. 2009 Aug 22 ;374(9690):620-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: