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    Protein Pept Lett. 2010 Mar;17(3):351-5.

    Mutagenesis studies of human cystathionine beta-synthase: residues important for heme binding and substrate interactions.

    Ozaki S, Sakaguchi C, Nakahara A, Yoshiya M.

    Source

    Department of Biological Sciences, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan. ozakis@yamaguchi-u.ac.jp

    Abstract

    Human cystathionine beta-synthase (CBS) is a pyridoxal 5'-phosphate (PLP) dependent hemoprotein, which catalyzes the condensation of serine and homocysteine. Our mutagenesis studies suggest that Arg-266 is important to sense structural changes in heme-binding site, and that Gln-222 as well as Tyr-223 are involved in interactions with substrates.

    PMID:
    19594435
    [PubMed - indexed for MEDLINE]

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