Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Sleep Med. 2010 Mar;11(3):310-3. doi: 10.1016/j.sleep.2009.04.005. Epub 2009 Jul 9.

Pregnancy accounts for most of the gender difference in prevalence of familial RLS.

Author information

  • 1Dept. of Psychology and Brain Science, Johns Hopkins Univ., Baltimore, MD, USA.

Abstract

OBJECTIVE:

This study was designed to evaluate the associated risk of RLS with pregnancy in relation to the family history and the age of symptom onset of RLS.

METHODS AND SUBJECTS:

Data from a prior RLS family history study in which 1019 subjects (527 males, 492 females) were interviewed, provided a diagnosis and characterization of RLS and determination of pregnancy status on which the current study analysis was undertaken.

RESULTS:

In the family members of RLS probands, the prevalence of RLS was significantly higher for parous women than for nulliparous women (49.5% vs. 33.7%, OR=1.92, 95% CI=1.16-3.19) or for men (49.5% vs. 30.0%, OR 2.29, 1.69-3.10), but no different for nulliparous women compared to men (33.7% vs. 30.0%, OR 1.19, 0.72-1.96). When only those whose RLS started at or after age 30 were considered, similar differences occurred. These differences were not observed among family members of control probands.

CONCLUSIONS:

These data indicate pregnancy has a major impact on the risk of developing RLS for those with a family history of RLS. This pregnancy effect appears to account for most of the gender differences often reported in overall RLS prevalence data.

Copyright 2009 Elsevier B.V. All rights reserved.

PMID:
19592302
[PubMed - indexed for MEDLINE]
PMCID:
PMC2830334
Free PMC Article

Images from this publication.See all images (2)Free text

Chart 1
Chart 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk