Format

Send to:

Choose Destination
See comment in PubMed Commons below
Org Biomol Chem. 2009 May 7;7(9):1753-60. doi: 10.1039/b821578b. Epub 2009 Mar 6.

Triggering cryptic natural product biosynthesis in microorganisms.

Author information

  • 1Leibniz Institute for Natural Product Research and Infection Biology, (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.

Abstract

Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it seems that many valuable compounds are overlooked when culturing microbes under standardized laboratory conditions. Many biosynthesis genes remain silent and such "cryptic" or "orphan" pathways are only activated under specific conditions. This report gives an overview on the strategies to trigger biosynthetic pathways to yield "cryptic natural products" through external cues, co-cultivation and genomic approaches such as genome-mining, epigenetic remodeling, and engineered pathway activation.

PMID:
19590766
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Write to the Help Desk