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J Pharm Pharmacol. 2009 Jul;61(7):961-7. doi: 10.1211/jpp/61.07.0017.

Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses.

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  • 1Laboratory of Inflammation, Department of Pharmacy and Pharmacology, State University of Maringá, Maringá, Paraná, Brazil.

Abstract

OBJECTIVES:

The immunomodulatory effect of ginger, Zingiber officinale (Zingiberaceae), sage, Salvia officinalis (Lamiaceae) and clove, Syzygium aromaticum (Myrtaceae), essential oils were evaluated by studying humor- and cell-mediated immune responses.

METHODS:

Essential oils were administered to mice (once a day, orally, for a week) previously immunized with sheep red blood cells (SRBCs).

KEY FINDINGS:

Clove essential oil increased the total white blood cell (WBC) count and enhanced the delayed-type hypersensitivity (DTH) response in mice. Moreover, it restored cellular and humoral immune responses in cyclophosphamide-immunosuppressed mice in a dose-dependent manner. Ginger essential oil recovered the humoral immune response in immunosuppressed mice. Contrary to the ginger essential oil response, sage essential oil did not show any immunomodulatory activity.

CONCLUSIONS:

Our findings establish that the immunostimulatory activity found in mice treated with clove essential oil is due to improvement in humor- and cell-mediated immune response mechanisms.

PMID:
19589240
[PubMed - indexed for MEDLINE]
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