Clin Infect Dis. 2009 Aug 15;49(4):584-7.

Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control.

Kirkland KB, Talbot EA, Decker MD, Edwards KM.

Department of Medicine, Section of Infectious Disease and International Health, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. kathy.kirkland@hitchcock.org

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Clin Infect Dis. 2009 Aug 15;49(4):588-90.

We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.

PMID: 19589084 [PubMed - indexed for MEDLINE]

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Bordetella pertussis booster vaccination for health care personnel immediately following a pertussis outbreak in a hospital?
Clin Infect Dis. 2009 Aug 15; 49(4):588-90.

[Clin Infect Dis. 2009]
Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel.
MMWR Recomm Rep. 2006 Dec 15; 55(RR-17):1-37.

[MMWR Recomm Rep. 2006]
Immunogenicity of reduced antigen content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine.
Vaccine. 2007 Jul 20; 25(29):5248-52. Epub 2007 Jun 4.

[Vaccine. 2007]
ReviewReduced-antigen, combined diphtheria-tetanus-acellular pertussis vaccine, adsorbed (Boostrix) US formulation): use as a single-dose booster immunization in adolescents aged 10-18 years.
Paediatr Drugs. 2006; 8(3):189-95; discussion 196.

[Paediatr Drugs. 2006]
ReviewPrevention of pertussis, tetanus, and diphtheria among pregnant and postpartum women and their infants recommendations of the Advisory Committee on Immunization Practices (ACIP).
MMWR Recomm Rep. 2008 May 30; 57(RR-4):1-51.

[MMWR Recomm Rep. 2008]
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Tetanus and Diphtheria Vaccine
Information regarding the tetanus and diphtheria vaccine (Td) has been merged with the monograph for tetanus, diphetheria, and pertussis (Tdap) vaccine.
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Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control.

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