J Steroid Biochem Mol Biol. 1991;40(1-3):271-8.

Progestin receptors: isoforms and antihormone action.

Gronemeyer H, Meyer ME, Bocquel MT, Kastner P, Turcotte B, Chambon P.

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Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

Abstract

We present evidence that the two isoforms of A and B of the chicken (cPR) and human progesterone receptor (hPR) originate from two different mRNA populations. One of these encodes the isoforms A which originate by initiation of translation at an in-frame AUG found 127 (cPR) and 165 (hPR) codons downstream of the AUG which gives rise to the isoforms B. Two estrogen-inducible hPR promoters were identified which are responsible for the generation of these two classes of transcripts. Characterization of the cPR promoter suggested the possible existence of cell-type and isoform-specific auto-regulation of cPR transcription and provided evidence that estrogen-induction of cPR expression occurs at a post-transcriptional level. Finally, we demonstrate promoter-specific transcriptional activation by the hPR isoforms A and B, and we discuss the mechanism of action of the anti-progestin RU486.

PMID:: 1958531; [PubMed - indexed for MEDLINE]

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Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms. [J Biol Chem. 1990]
Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.
Kastner P, Bocquel MT, Turcotte B, Garnier JM, Horwitz KB, Chambon P, Gronemeyer H. J Biol Chem. 1990 Jul 25; 265(21):12163-7.
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Meyer ME, Pornon A, Ji JW, Bocquel MT, Chambon P, Gronemeyer H. EMBO J. 1990 Dec; 9(12):3923-32.
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Review The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.
Giangrande PH, McDonnell DP. Recent Prog Horm Res. 1999; 54:291-313; discussion 313-4.
Review The estrogen receptor gene: promoter organization and expression. [Int J Biochem Cell Biol. 1997]
Review The estrogen receptor gene: promoter organization and expression.
Grandien K, Berkenstam A, Gustafsson JA. Int J Biochem Cell Biol. 1997 Dec; 29(12):1343-69.

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Cited by 6 PubMed Central articles

Review Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. [Nucl Recept Signal. 2009]
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