Immunol Today. 1991 Oct;12(10):370-4.

Modulation of T-cell function by gliomas.

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Dept of Microbiology and Immunology, University of Kentucky Medical Center, Lexington 40536.

Abstract

Patients with primary intracranial tumors (gliomas) exhibit a profound decrease in immunity, the mechanism of which has, until recently, remained obscure. Here Thomas Roszman, Lucinda Elliott and William Brooks reveal that T cells obtained from these patients exhibit defects in interleukin 2 secretion and in expression of the high-affinity IL-2 receptor and they discuss the role played by immunosuppressive factors produced by gliomas in inducing these defects.

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Immunol Today. 1992 Apr;13(4):148.

PMID:: 1958290; [PubMed - indexed for MEDLINE]

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Review Immune defects observed in patients with primary malignant brain tumors. [J Neuroimmunol. 1999]
Review Immune defects observed in patients with primary malignant brain tumors.
Dix AR, Brooks WH, Roszman TL, Morford LA. J Neuroimmunol. 1999 Dec; 100(1-2):216-32.
Apoptotic elimination of peripheral T lymphocytes in patients with primary intracranial tumors. [J Neurosurg. 1999]
Apoptotic elimination of peripheral T lymphocytes in patients with primary intracranial tumors.
Morford LA, Dix AR, Brooks WH, Roszman TL. J Neurosurg. 1999 Dec; 91(6):935-46.
Inability of mitogen-activated lymphocytes obtained from patients with malignant primary intracranial tumors to express high affinity interleukin 2 receptors. [J Clin Invest. 1990]
Inability of mitogen-activated lymphocytes obtained from patients with malignant primary intracranial tumors to express high affinity interleukin 2 receptors.
Elliott LH, Brooks WH, Roszman TL. J Clin Invest. 1990 Jul; 86(1):80-6.
Role of interleukin-2 (IL-2) and IL-2 receptor expression in the proliferative defect observed in mitogen-stimulated lymphocytes from patients with gliomas. [J Natl Cancer Inst. 1987]
Role of interleukin-2 (IL-2) and IL-2 receptor expression in the proliferative defect observed in mitogen-stimulated lymphocytes from patients with gliomas.
Elliott L, Brooks W, Roszman T. J Natl Cancer Inst. 1987 May; 78(5):919-22.
Review The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain. [Brain Res Brain Res Rev. 1995]
Review The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain.
Weller M, Fontana A. Brain Res Brain Res Rev. 1995 Sep; 21(2):128-51.

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Cited by 12 PubMed Central articles

Review Immunotherapy coming of age: what will it take to make it standard of care for glioblastoma? [Neuro Oncol. 2011]
Review Immunotherapy coming of age: what will it take to make it standard of care for glioblastoma?
Heimberger AB, Sampson JH. Neuro Oncol. 2011 Jan; 13(1):3-13. Epub 2010 Dec 10.
Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone. [Neuro Oncol. 2010]
Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone.
Gustafson MP, Lin Y, New KC, Bulur PA, O'Neill BP, Gastineau DA, Dietz AB. Neuro Oncol. 2010 Jul; 12(7):631-44. Epub 2010 Feb 23.
Glioma-associated cancer-initiating cells induce immunosuppression. [Clin Cancer Res. 2010]
Glioma-associated cancer-initiating cells induce immunosuppression.
Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Sawaya R, et al. Clin Cancer Res. 2010 Jan 15; 16(2):461-73. Epub 2010 Jan 12.

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