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Amino Acids. 2010 Apr;38(4):1101-6. doi: 10.1007/s00726-009-0319-7. Epub 2009 Jul 7.

Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways.

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  • 1Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25124, Brescia, Italy.

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  • Amino Acids. 2010 Apr;38(4):1107. Giovanna, Cenini [corrected to Cenini, Giovanna].


A neuropathological characteristic of Alzheimer's disease is the extracellular accumulation of amyloid beta peptide (Abeta) in neuritic plaques. Recent evidences suggested that soluble Abeta oligomers are the predominant neurotoxic species for neurons. Thus, considerable attention has been paid to discriminate the cytotoxic pathways of Abeta pre-fibrillar aggregates and mature fibrils. We showed that the mechanisms by which Abeta oligomers and fibrils generated reactive oxygen species differ in terms of site of production and kinetics, suggesting the involvement of different intra/extracellular pathways.

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