Send to:

Choose Destination
See comment in PubMed Commons below
Oncogene. 2009 Sep 3;28(35):3093-6. doi: 10.1038/onc.2009.173. Epub 2009 Jul 6.

Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase.

Author information

  • 1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck A-6020, Austria.


Despite the early discovery of caspase-2, its physiological function has long remained an enigma. A number of recent publications now suggest not just one, but multiple functions, including roles in apoptosis, DNA repair and tumor suppression. How can one enzyme have so many talents? Considering the diversity of interaction partners and the specific mode of pro-apoptotic action proposed in these studies, caspase-2 might in fact represent a primordial protease serving numerous pathways, established before the advent of a more elaborate functionally diversified caspases system.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk