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Prostate Cancer Prostatic Dis. 2010 Mar;13(1):6-11. doi: 10.1038/pcan.2009.29. Epub 2009 Jul 7.

The role of caveolin-1 in prostate cancer: clinical implications.

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  • 1Department of Genitourinary Medical Oncology-Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. timthomp@mdanderson.org

Abstract

Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.

PMID:
19581923
[PubMed - indexed for MEDLINE]
PMCID:
PMC2887695
Free PMC Article
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