Nat Nanotechnol. 2009 Jul;4(7):411-4. Epub 2009 Jun 28.

Evaluation of nanoparticle immunotoxicity.

Dobrovolskaia MA, Germolec DR, Weaver JL.

Source

Nanotechnology Characterization Laboratory, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA. marina@mail.nih.gov

Abstract

The pharmaceutical industry is developing increasing numbers of drugs and diagnostics based on nanoparticles, and evaluating the immune response to these diverse formulations has become a challenge for scientists and regulatory agencies alike. An international panel of scientists and representatives from various agencies and companies reviewed the imitations of current tests at a workshop held at the National Cancer Institute in Frederick, Maryland. This article outlines practical strategies for identifying and controlling interferences in common evaluation methods and the implications for regulation.

PMID:: 19581891; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, N.I.H., Extramural

MeSH Terms

Substances

Immunotoxins

Grant Support

HHSN261200800001E/PHS HHS/United States

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