Abstract
Acinetobacter baumannii has been increasingly associated with hospital-acquired infections, and the presence of multidrug resistance strains is of great concern to clinicians. A. baumannii is thought to possess a great deal of intrinsic resistance to several antimicrobial agents, including chloramphenicol, although the mechanisms involved in such resistance are not well understood. In this work, we have identified a major facilitator superfamily efflux pump present in most A. baumannii strains, displaying strong substrate specificity toward chloramphenicol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics
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Aminoglycosides / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology*
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Chloramphenicol Resistance / genetics*
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Drug Resistance, Multiple, Bacterial / genetics*
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Imipenem / pharmacology
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Microbial Sensitivity Tests
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Polymerase Chain Reaction
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Quinolones / pharmacology
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Tetracyclines / pharmacology
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bacterial Proteins
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Quinolones
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Tetracyclines
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Imipenem