Exp Gerontol. 2009 Sep;44(9):607-12. Epub 2009 Jul 4.

Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.

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Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA. Deqing.wu@gmail.com

Abstract

Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects life-long mortality by decreasing initial mortality only; the rate of increase in subsequent mortality (Gompertz component) is unchanged. Repeated mild heat-shocks throughout life have a larger effect on life span than does a single heat-shock early in life. Here, we ask how multiple heat-shocks affect the mortality trajectory in nematodes and find increases of life expectancy of close to 50% and of maximum longevity as well. We examined mortality using large numbers of animals and found that multiple heat-shocks not only decrease initial mortality, but also slow the Gompertz rate of increase in mortality. Thus, multiple heat-shocks have anti-aging hormetic effects and represent an effective approach for modulating aging.

PMID:: 19580861; [PubMed - indexed for MEDLINE]
PMCID: PMC2753291

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Heat-Shock Proteins

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