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Antioxid Redox Signal. 2009 Nov;11(11):2673-83. doi: 10.1089/ARS.2009.2730.

Mitochondrial regulation of cell survival and death during low-oxygen conditions.

Snyder CM, Chandel NS.

Source

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School , Chicago, Illinois, USA.

Abstract

Mitochondria can initiate cell death or activate genes that promote cell survival in response to low oxygen. The BCL-2 family of proteins regulate cell death in response to anoxia (0-0.5% O2). By contrast, under hypoxia (0.5-3% O2), mitochondrial oxidative stress activates hypoxia-inducible factors (HIFs) to promote cell survival. In this review, we discuss how mitochondria, BCL-2 proteins, and HIFs are crucial for cellular responses to low oxygen.

PMID:: 19580395; [PubMed - indexed for MEDLINE]
PMCID:: PMC2821141

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R01CA123067-03/CA/NCI NIH HHS/United States

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