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Clin Nutr. 2010 Feb;29(1):24-30. doi: 10.1016/j.clnu.2009.06.004. Epub 2009 Jul 2.

Relationships between cardiovascular risk profile, ultrasonographic measurement of intra-abdominal adipose tissue, and waist circumference in obese children.

Author information

  • 1Institute of Paediatric Nutrition Medicine, Vestische Kinder- und Jugendklinik, University of Witten/Herdecke, Dr. F. Steiner Strasse 5, 45711 Datteln, Germany. t.reinehr@kinderklinik-datteln.de

Abstract

BACKGROUND & AIMS:

Ultrasonographic measurements have been proposed to assess intra-abdominal adipose tissue. The aim of this study was to compare the relationship between waist circumference (WC), ultrasonographic measurements of intra-abdominal adipose tissue (UMA), and cardiovascular risk factors (CRF).

METHODS:

We determined blood pressure (BP), fasting HDL-cholesterol, LDL-cholesterol, triglycerides, glucose, insulin resistance index HOMA, 2 h glucose in oral glucose tolerance test (oGTT), weight status (SDS-BMI), WC, and UMA in 89 obese children. Furthermore, we analyzed the changes of CRF, SDS-BMI, WC, and UMA in 29 obese children participating in a one-year lifestyle intervention.

RESULTS:

In stepwise multivariable regression analysis, waist circumference was significantly associated to LDL-cholesterol, triglycerides, HOMA, and systolic blood pressure (adjusted variance (AV) 0.05-0.17). SDS-BMI was significantly related to triglycerides, HDL-cholesterol, 2 h glucose in oGTT, and diastolic blood pressure (AV 0.12-0.15), while UMA was related significantly to HOMA (AV 0.04). The obese children participating in a lifestyle intervention significantly reduced their overweight, which was associated with a significant improvement of most CRF and a reduction of WC and UMA. Changes of WC were significantly correlated to changes of HDL-cholesterol (r=-0.45), HOMA (r=0.37), glucose tolerance (r=0.59), systolic BP (r=0.60), and diastolic BP (r=0.43), while change of SDS-BMI and UMA were not significantly related to any CRF.

CONCLUSIONS:

Compared to UMA, WC was stronger related to CRF in obese children. Therefore, the simple measurement of WC seems preferable as an indirect marker of CRF.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00435734.

Copyright 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

[PubMed - indexed for MEDLINE]
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