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Cancer Cell. 2009 Jul 7;16(1):5-7. doi: 10.1016/j.ccr.2009.06.009.

Actin-based protrusions: promoters or inhibitors of cancer invasion?

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  • 1The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, Scotland. l.machesky@beatson.gla.ac.uk


In a recent issue of Cell, Silva and colleagues reported the identification of CYFIP1, a member of the actin-assembly-promoting Scar/WAVE complex, as an invasion suppressor in epithelial cancers. This study challenges ideas about the role of actin in cancer invasion.

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