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J Clin Psychiatry. 2009 Aug;70(8):1178-85. doi: 10.4088/JCP.08m04696. Epub 2009 Jun 30.

Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?

Author information

  • 1Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 185 Alewife Brook Pkwy, Suite 2000, Cambridge, MA 02138, USA. ahenin@partners.org

Abstract

OBJECTIVE:

To evaluate the impact of psychopharmacologic treatments on neuropsychological functioning in bipolar youth.

METHOD:

Participants were 173 children (aged 6-17 years) with DSM-IV bipolar disorder. Participants were comprehensively assessed using structured diagnostic interviews (Schedule for Affective Disorders and Schizophrenia for School-Age Children) and neuropsychological measures (eg, subtests of the Wechsler Intelligence Scale for Children-III and Wechsler Adult Intelligence Scale-III) during the years 2001-2006. Comparisons were made in neuropsychological functioning between medicated and unmedicated youth with bipolar disorder.

RESULTS:

Children who were treated with mood stabilizers performed significantly (P < .05) more poorly than untreated children on measures of processing speed and working memory. Treatment with other classes of medication, including second-generation antipsychotics, was not significantly associated with neuropsychological impairments.

CONCLUSIONS:

Treatment with mood stabilizers may be associated with specific neuropsychological impairments. Cognitive side effects may need to be considered in selecting particular psychopharmacologic treatments for children with bipolar disorder.

┬ęCopyright 2009 Physicians Postgraduate Press, Inc.

PMID:
19573494
[PubMed - indexed for MEDLINE]
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