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Nature. 2009 Jul 2;460(7251):49-52. doi: 10.1038/nature08180.

Elite and stochastic models for induced pluripotent stem cell generation.

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  • 1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.


Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.

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