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Clin Pharmacol Ther. 2009 Nov;86(5):507-10. doi: 10.1038/clpt.2009.103. Epub 2009 Jul 1.

Systematic evaluation of drug-disease relationships to identify leads for novel drug uses.

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  • 1Department of Medicine, Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA.


Drug repositioning refers to the discovery of alternative uses for drugs--uses that are different from that for which the drugs were originally intended. One challenge in this effort lies in choosing the indication for which a drug of interest could be prospectively tested. We systematically evaluated a drug treatment-based view of diseases in order to address this challenge. Suggestions for novel drug uses were generated using a "guilt by association" approach. When compared with a control group of drug uses, the suggested novel drug uses generated by this approach were significantly enriched with respect to previous and ongoing clinical trials.

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