Display Settings:


Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Biol Pharm Bull. 2009 Jul;32(7):1199-203.

Estrogen-related receptor alpha inverse agonist enhances basal glucose uptake in myotubes through reactive oxygen species.

Author information

  • 1Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou International Business Incubator.


Estrogen-related receptors alpha (ERRalpha) and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) function coordinately to regulate mitochondrial biogenesis and oxidative phosphorylation particularly in muscle tissue. In this study, we addressed the consequences of suppressing the activity of ERRalpha in L6 myotubes using an ERRalpha inverse agonist XCT-790. We found that treating differentiated L6 myotubes with XCT-790 reduced the expression of PGC-1alpha and suppressed mitochondrial biogenesis. Additionally, XCT-790 increased the production of reactive oxygen species (ROS) which in turn induced the expressions of glucose transporters 1, 2, and 5 leading to an increase in glucose uptake and uncoupling protein 3 leading to a reduction of mitochondrial membrane potential. Thus, suppressing the activity of ERRalpha which is primarily responsible for controlling beta-oxidation would nonetheless indirectly affect glucose uptake in a ROS-dependent manner.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
    Loading ...
    Write to the Help Desk