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    Br J Ophthalmol. 2009 Oct;93(10):1378-81. Epub 2009 Jun 30.

    No association of CTLA-4 polymorphisms with susceptibility to Behçet disease.

    Du L, Yang P, Hou S, Zhou H, Kijlstra A.

    The First Affiliated Hospital, Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, PR China.

    BACKGROUND: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T lymphocytes and has been shown to be associated with a number of autoimmune diseases. The present study was performed to assess the association between CTLA-4 polymorphisms and Behçet disease (BD) in Chinese patients. METHODS: Two hundred and twenty-eight BD patients and 207 controls were analysed for four single nucleotide polymorphisms (SNPs) (-1661A/G, -318C/T, +49G/A and CT60G/A) in the CTLA-4 gene by PCR-restriction fragment length polymorphism (RFLP) analysis. The association between SNP +49A/G and BD in Chinese population as well as other ethnic groups was analysed by meta-analysis. RESULTS: No association could be detected between CTLA-4 SNPs or haplotypes and BD. Also, no association was observed between CTLA-4 polymorphisms and BD subgroups, stratified by clinical features. A meta-analysis showed that there was no heterogeneity between studies (p = 0.60, I(2) = 0%) and that CTLA-4 SNP +49 was not associated with BD (overall effect: Z = 0.26, p = 0.79). CONCLUSION: This study and a meta-analysis failed to demonstrate any association between the tested CTLA-4 polymorphisms and BD.

    PMID: 19570770 [PubMed - indexed for MEDLINE]

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