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Cell Stem Cell. 2009 Jul 2;5(1):6-8. doi: 10.1016/j.stem.2009.06.006.

Stem cell aging and aberrant differentiation within the niche.

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  • 1Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.


Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or senescence.

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