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Pharmacol Res. 1991 Oct;24(3):227-33.

The influence of age on the pharmacokinetics of verapamil.

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  • 1University Department of Medicine and Therapeutics, Stobhill General Hospital, Glasgow, Scotland, UK.

Abstract

The influence of age on the pharmacokinetics of verapamil at steady state has been studied in 74 individuals, age range 19-79 years, including healthy normotensive volunteers and patients with essential hypertension. The peak plasma concentrations (Cmax) of verapamil were significantly higher in older subjects (r = 0.24; P = 0.03) and there was a non-significant age-related decrease in clearance/F and a non-significant increase in elimination half-life. These results suggest that increasing age is associated with changes in the pharmacokinetics of verapamil but these changes are small and unlikely to be of clinical significance.

PMID:
1956867
[PubMed - indexed for MEDLINE]
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