Yonsei Med J. 2009 Jun 30;50(3):445-7. Epub 2009 Jun 23.

A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug.

Lee SM, Kim HM, Lee JS, Yoon CS, Park MS, Park KI, Namgung R, Lee C.

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Department of Pediatrics, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu,Seoul, Korea.

Abstract

Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both-ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotretinoin are needed.

PMID:: 19568610; [PubMed - indexed for MEDLINE]
PMCID:: PMC2703771

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