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Sci Signal. 2009 Jun 30;2(77):pe39. doi: 10.1126/scisignal.277pe39.

AIMing 2 detect foreign DNA.

Author information

  • 1Pfizer Research Technology Center, 620 Memorial Drive, Cambridge, MA 02139, USA. arthur.krieg@pfizer.com

Abstract

Foreign genomic DNA can be detected by immune cells in the cytoplasm, triggering reactions such as cell death and secretion of proinflammatory cytokines, including interleukin 1beta (IL-1beta). Several studies have now elucidated the mechanism for this response. The HIN-200 (hematopoietic interferon-inducible nuclear proteins with a 200-amino acid repeat) family member AIM2 (absent in melanoma 2) binds and oligomerizes on cytoplasmic DNA through a HIN domain. The oligomerized AIM2 recruits the adaptor ASC (apoptosis-associated specklike protein containing a CARD) through homotypic pyrin domain interactions and binds caspase-1, forming an inflammasome that generates IL-1beta. Together with previous studies, this work demonstrates that immune detection of foreign nucleic acids occurs through several distinct signaling pathways, leading to diverse immune outcomes.

PMID:
19567913
[PubMed - indexed for MEDLINE]
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