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Ann N Y Acad Sci. 2009 Jun;1168:23-51. doi: 10.1111/j.1749-6632.2009.04880.x.

Evolutionary theory of cancer.

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  • 1Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Abstract

As Theodosius Dobzhansky famously noted in 1973, "Nothing in biology makes sense except in the light of evolution," and cancer is no exception to this rule. Our understanding of cancer initiation, progression, treatment, and resistance has advanced considerably by regarding cancer as the product of evolutionary processes. Here we review the literature of mathematical models of cancer evolution and provide a synthesis and discussion of the field.

PMID:
19566702
[PubMed - indexed for MEDLINE]
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