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J Mol Genet Med. 2005 Aug 3;1(1):11-7.

Significance of the Y-box proteins in human cancers.

Author information

  • 1Laboratory of Cellular Biochemistry, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Abstract

Y-box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control. Here, we give a brief overview of the structure, regulation and physiological functions of the Y-box proteins. This is followed by examining the role of Y-box protein 1 (YB-1), the most extensively studied of the Y-box protein in tumorigenesis, and its clinicopathological significance. YB-1 has the potential to be a prognostic marker and predictor of chemoresistance in human cancers.

KEYWORDS:

YB-1; chemoresistance; clinicopathological significance; prognostication; structure and regulation; tumorigenesis

PMID:
19565008
[PubMed]
PMCID:
PMC2702063
Free PMC Article
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