Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2009 Jun 26;137(7):1194-211. doi: 10.1016/j.cell.2009.06.001.

CTCF: master weaver of the genome.

Author information

  • 1Department of Biology, Emory University, Atlanta, GA 30322, USA. jephill@emory.edu

Abstract

CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.

PMID:
19563753
[PubMed - indexed for MEDLINE]
PMCID:
PMC3040116
Free PMC Article

Images from this publication.See all images (6)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk