J Cardiovasc Electrophysiol. 2010 Feb;21(2):207-10. Epub 2009 Jun 26.

Sotalol and a broken heart.

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Cape Cod Hospital, Hyannis, Massachusetts, USA. plfriedman@msn.com

Abstract

An 82-year-old woman with persistent atrial fibrillation underwent successful electrical cardioversion and was begun on sotalol. After 3 days of in-hospital observation she had only mild lengthening of the QT interval. Two weeks later in clinic, the day after her husband's unexpected death, she was noted to have profound QT interval prolongation. Although she was asymptomatic and echocardiography did not disclose regional wall motion abnormalities consistent with takotsubo cardiomyopathy, she probably had a forme fruste of stress cardiomyopathy. Following emotional trauma, a period of heightened vigilance for ventricular proarrhythmia is probably warranted in women treated with antiarrhythmic drugs that lengthen repolarization.

PMID:: 19563362; [PubMed - indexed for MEDLINE]

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Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required? Yield of in-hospital monitoring and prediction of risk for significant arrhythmia complications. [J Am Coll Cardiol. 1998]
Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required? Yield of in-hospital monitoring and prediction of risk for significant arrhythmia complications.
Chung MK, Schweikert RA, Wilkoff BL, Niebauer MJ, Pinski SL, Trohman RG, Kidwell GA, Jaeger FJ, Morant VA, Miller DP, et al. J Am Coll Cardiol. 1998 Jul; 32(1):169-76.
Efficacy and proarrhythmic hazards of pharmacologic cardioversion of atrial fibrillation: prospective comparison of sotalol versus quinidine. [J Am Coll Cardiol. 1995]
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Hohnloser SH, van de Loo A, Baedeker F. J Am Coll Cardiol. 1995 Oct; 26(4):852-8.
Hemodynamic performances in patients treated with sotalol after electrical cardioversion of atrial fibrillation. [Rom J Intern Med. 1997]
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Review Sotalol: An important new antiarrhythmic.
Anderson JL, Prystowsky EN. Am Heart J. 1999 Mar; 137(3):388-409.
Review Practical considerations in the use of sotalol for ventricular tachycardia and ventricular fibrillation. [Am J Cardiol. 1993]
Review Practical considerations in the use of sotalol for ventricular tachycardia and ventricular fibrillation.
Campbell RW, Furniss SS. Am J Cardiol. 1993 Aug 12; 72(4):80A-85A.

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