Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Biosyst. 2009 Jul;5(7):704-13. doi: 10.1039/b901484e. Epub 2009 May 14.

Synthetic biology: exploring and exploiting genetic modularity through the design of novel biological networks.

Author information

  • 1Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Synthetic biology has been used to describe many biological endeavors over the past thirty years--from designing enzymes and in vitro systems, to manipulating existing metabolisms and gene expression, to creating entirely synthetic replicating life forms. What separates the current incarnation of synthetic biology from the recombinant DNA technology or metabolic engineering of the past is an emphasis on principles from engineering such as modularity, standardization, and rigorously predictive models. As such, synthetic biology represents a new paradigm for learning about and using biological molecules and data, with applications in basic science, biotechnology, and medicine. This review covers the canonical examples as well as some recent advances in synthetic biology in terms of what we know and what we can learn about the networks underlying biology, and how this endeavor may shape our understanding of living systems.

PMID:
19562109
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Write to the Help Desk