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J Allergy Clin Immunol. 2009 Jul;124(1):23-34; quiz 35-6. doi: 10.1016/j.jaci.2009.05.037.

Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches.

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  • 1Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, United Kingdom.

Abstract

The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure.

PMID:
19560576
[PubMed - indexed for MEDLINE]
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