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Semin Cell Dev Biol. 2009 Sep;20(7):842-8. doi: 10.1016/j.semcdb.2009.06.005. Epub 2009 Jun 26.

Towards a genome-wide reconstruction of cis-regulatory networks in the human genome.

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  • 1Department of Genetics, Yale University, School of Medicine, New Haven, CT 06510, United States.


The vast amount of recent progress made on the sequence of the human genome has allowed an unprecedented examination of cis-regulatory networks. These networks consist of functional elements such as promoters, enhancers, silencers, and insulators, and their coordinated activity is responsible for regulation of gene expression. Recent studies surveyed the entire genome, identifying novel elements and evaluating functional differences in respect to development. These investigations present the first steps towards a global regulatory map for expression in the human genome.

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