Laboratoire Stress Oxydants et Cancer, CEA-Saclay, 91191 Gif-sur-Yvette, France. michel.toledano@cea.fr
In this issue of Molecular Cell, Zhang and colleagues (Chen et al., 2009) report their identification of p21 as a positive regulator of Nrf2, which extends p53 prosurvival functions through recruitment of a master stress-response regulator.