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Curr Opin Biotechnol. 2009 Jun;20(3):272-9. doi: 10.1016/j.copbio.2009.06.003. Epub 2009 Jun 24.

Modular model-based design for heterologous bioproduction in bacteria.

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  • 1Synth-Bio group. Epigenomics Project, Universit√© d'Evry Val d'Essonne-Genopole-CNRS UPS3201, 91034 Evry, France.


We review the current status of expression of heterologous systems for bioenergy and bioproduction in bacteria using a model-based approach. As an aim for synthetic biology, it requires mathematical models of genetic modules that could be characterized independently of their context. This fastens the design of metabolic circuits using a combinatorial design approach, where given pathways could be optimized for maximal bioproduction, while being nontoxic for the chassis. We show how recent characterization of genetic parts, such as promoters, RBS or sRNAs could be used to fine-tune the expression of individual genes to achieve that goal. We also present lists of enzymes that are used for bioproduction, enlarging such set of biological parts.

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