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Clin Imaging. 2009 Jul-Aug;33(4):301-5. doi: 10.1016/j.clinimag.2009.01.013.

Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.

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  • 1Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.

PMID:
19559353
[PubMed - indexed for MEDLINE]
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